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Overall, these findings strongly support fisetin as a potential anti-inflammatory flavonoid that suppresses key inflammatory mediators such as TNF-α, IL-1β, IL-6, COX-2, iNOS, NF-κB, and MAPK while regulating upstream kinases and epigenetic modulators

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doi: 10.1016/j.exer.2005.02.009 151 MeyerLMLöfgrenSHolzFGWegenerASöderbergP