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This study demonstrated that ERT not only ameliorated structural deformities but also reduced oxidative stress and increased the gene expression of kidney cells in Fabry kidney organoids, which means that Fabry kidney organoids are useful tools for investigating the efficacy of ERT and will contribute to the development of new forms of ERT

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With the combination of Vitamin B12 supplementation, dietary changes, and moderation in alcohol consumption, Sarah starts experiencing improvements in her energy levels, gastrointestinal symptoms, and overall well-being