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In phosphorylation-dependent processes, GRK2 can regulate signaling mediated by other membrane receptor families, except for GPCRs, including RTKs for epidermal growth factor receptor (EGFR) ( via phosphorylation ( GRK2 may also contribute to the modulation of cellular responses in a phosphorylation-independent manner as a result of its ability to interact with a plethora of proteins involved in signaling and trafficking, including G protein subunits, such as Gαq and Gβγ

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10.1038/ajg.2012.211 282