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2.3 Diagnosis and management Peripheral fatigue can be quantified through objective assessments of strength and aerobic capacity, while central fatigue is evaluated using self-reports and validated questionnaires that capture the patient’s perception of physical and mental exertion impacts on their activities and exertion levels
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Systemic effects that have been reported in trials, or that are mechanistically expected from elevated GH and IGF-1, include: Water retention and mild edema , particularly in the hands, ankles, and face Tingling, numbness, or 'pins and needles' (paresthesia) , sometimes linked to fluid pressure on nerves Headache and facial flushing , often shortly after administration Joint aches or stiffness (arthralgia) Transient changes in blood glucose due to GH's counter-regulatory effect on insulin Fatigue, dizziness, or a feeling of light-headedness in some individuals It is important to be candid about the limits of this evidence
