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However, it has remained unclear how mitragynine acts as such a potent opioid antinociceptive despite having 50-fold weaker MOR binding affinity (230 nM) than morphine (4.6 nM) and only modest in vitro agonist potency (EC 50 = 203 nM) and low efficacy at MOR (Table 1)

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The public COA library was a deciding factor — no other supplier I’ve used offers that level of transparency.” “We source BPC-157 from several suppliers for comparative studies