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4 From eNOS uncoupling to hypertension: several molecular mechanisms contribute to the pathology establishment The altered NO production may be involved in the essential hypertension pathogenesis, as human studies showed that an increase in the mean diurnal BP corresponded with a reduced urinary excretion of nitrate, an index of endogenous NO generation

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Serin IS, Ozcelik B, Basbug M, Aygen E, Kula M, Erez R