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Signs and Symptoms of Hyperthyroidism Hyperthyroidism can cause a wide range of symptoms, including: Sudden or rapid, unexplained weight loss Increased appetite Rapid or irregular heartbeat Feeling nervous or anxious Irritability Difficulty sleeping Tremor, trembling in your hands and fingers Increased sweating Feeling hot Muscle weakness Diarrhea or frequent bowel movements Lighter and fewer menstrual periods Redness, irritation or bulging of the eyes Fine, brittle hair Thinning skin Causes of Hyperthyroidism There are a number of factors that can cause the thyroid to produce too much of the thyroid hormones, including: Graves’ disease: The most common cause of hyperthyroidism, Graves’ disease, is an autoimmune disorder in which antibodies attach the thyroid gland causing it to produce too much T-4 hormone

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But they engage different receptor systems , sit at different evidence tiers , and carry very different regulatory status