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The sophisticated process of mitochondrial biogenesis requires coordination between mtDNA and nDNA, including mtDNA transcription and translation, translation of nDNA-encoded transcripts, membrane recruitment, protein import, and assembly of the OXPHOS complexes (Wu et al., 1999), and PPARG coactivator 1 beta (PGC1β) along with PPARG related-coactivator 1 (PRC) were discovered subsequently (Patel et al., 2012

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