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Endothelial NOS (eNOS): eNOS, found primarily in endothelial cells, plays a critical role in regulating vascular tone and blood pressure

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Animal research suggests that a single dose of curcumin, a constituent of turmeric, may increase tramadol's maximum concentration (Cmax) by inhibiting metabolism, while continued daily use for 7 days may reduce the area under the curve (AUC) due to the induction of drug-metabolizing enzymes such as cytochrome P450 3A4 (CYP3A4)