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Anticancer Res (1998) 18:3433–7

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KEAP1 is the recognition site for redox-dependent CULLIN 3 (Cul3)-based (or CUL3–ring-box 1 (Rbx1)-containing) E3 ubiquitin ligase, which degrades Nrf2 (Figure 3)—i.e., KEAP1 acts as an adaptor protein for ubiquitin ligase, which is responsible for the ubiquitylation and subsequent degradation of Nrf2 through the proteasome (26s) system [262,263]

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