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the most common were dry mouth and insomnia.β β Astrup et al., The Lancet β Who Should Avoid Tesofensine β Individuals with uncontrolled hypertension or cardiovascular disease β Anyone on SSRIs, SNRIs, or MAO inhibitors (risk of serotonin syndrome) β Those with a history of severe anxiety, panic disorder, or arrhythmias β Pregnant or breastfeeding women (due to lack of safety data) β Best Practices for Safety β Start at 0.25 mg/day and gradually titrate β Avoid stacking with caffeine , yohimbine , or stim-heavy pre-workouts β Monitor blood pressure, heart rate, and sleep quality β Discontinue use if side effects worsen or persist beyond the adaptation period (7β10 days) Although Tesofensine has a relatively clean side effect profile at moderate doses, itβs still a powerful central agent
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