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FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation | Communications Biology

Curiously, like the livers of Gsr-null mice reported a decade earlier by Rogers and colleagues [110], TrxR1/Gsr-null livers exhibit no detectable GSSG-reductase activity, yet they maintain normal or higher levels of total GSH, of which nearly all is in the reduced form [107, 108]

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Mitochondrial GSTs are known as the kappa class in mammals and are mostly found in the mitochondrial matrix 60 and peroxisomes 61