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However, if saturated fatty acids accumulate in excess in cells, they become toxic and induce the generation of ROS, endoplasmic reticulum stress and NLRP3 inflammasome activation, which are all associated with a pro-inflammatory macrophage phenotype (Legrand-Poels et al., 2014)

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While this patient has lung findings, the bilateral hilar lymphadenopathy and interstitial infiltrates strongly favor sarcoidosis over a primary squamous cell lung malignancy