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Assessing the tissue ET concentrations of control mice, we found that of the 10 tissues measured (expressed in mass per wet weight of tissue ± standard error), liver had the highest amount of ET (80.65 ± 4.14 ng/mg), followed by whole blood (58.99 ± 2.05 ng/µl blood), spleen (36.45 ± 3.72 ng/mg), kidney (27.61 ± 2.61 ng/mg), lung (19.56 ± 1.46 ng/mg), heart (12.09 ± 1.20 ng/mg), small intestine (7.23 ± 0.86 ng/mg), eye (5.40 ± 0.29 ng/mg), large intestine (4.37 ± 0.93 ng/mg) and brain (3.73 ± 0.59 ng/mg) (Fig

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91 A detailed history, including other dermatological conditions, current oral and topical medications, history of herpes simplex virus (HSV) infection, past reactions to other cosmetic procedures, and a skin examination should be obtained prior to the procedure