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Serum holoTC is a better biomarker of recent B12 intake than serum B12 (or methymalonic acid or tHcy) because serum holoTC concen­trations increase much faster after ingestion of B12 from a meal (i.e., 6 hours) or crystal­line B12 from supple­ments

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The use of combination therapy in settings such as hypertension, tuberculosis, HIV infection, and many cancers highlights potential for such a “systems biology” view of drug therapy