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First, ROS directly modifies ion channels, oxidizing sulfhydryl groups on voltage-gated Na+ channels, resulting in abnormal action potential propagation and contributing to the paradoxical coexistence of pain and numbness (Elafros et al., 2022)

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Under the optimized experimental conditions, keeping the acquisition method and average times constant, the enhancement factor was calculated to be 128 with the intensity at the characteristic absorption peak of 1,654 cm −1