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In the presence of a transitional metal ion, lipid peroxide is catalyzed into OH • ( The sustained lipid peroxidation chain reaction results in progressive loss of membrane fatty acids, with consequent decrease in membrane fluidity, increased non-specific permeability to ions, and inhibition of membrane bound receptors and enzymes ( Besides their role in mediating lipid peroxidation, ROS especially nitric oxide (NO • ), and OH • ( ROS has also been implicated as an apoptotic stimulus that triggers the mitochondria to release some signaling molecules crucial for the activation of programmed cell death (98)

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