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Summary of Centers for Disease Control and Prevention Guideline Clinicians should Prescribe the lowest effective dosage when initiating opioid therapy Use caution when prescribing opioids at any dosage Carefully reassess benefits and risks when increasing dosage to 50 morphine milligram equivalents (MME)/day Avoid increasing dosage to 90 MME/day Many states codified these voluntary recommendations through statutes or regulations that imposed enforceable limitations on medical professionals’ ability to prescribe or dispense opioids for pain treatment