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This decline has led some researchers to speculate that reduced GHK signaling could contribute to age-related impairments in: wound healing tissue repair collagen production While this hypothesis remains under investigation, it helps explain why GHK-Cu supplementation—particularly through topical formulations—has become a focus of dermatologic research

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Angiogenesis is triggered by a lack of oxygen in the area which signal endothelial cells of the vasculature to release nitric oxide, which in turn stimulates the release of endothelial growth factor