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Eryptosis and cigarette smoke Cigarette smoking is well-established as a significant contributor to oxidative stress and systemic inflammation, both of which are key drivers of various pathological conditions, including cardiovascular and pulmonary diseases [232]

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With the advent of cloning, a number of discoveries were made, including of the discovery of the GPCR superfamily [18], the cloning of the G protein receptor kinases (GRKs) [19, 20] and of β-arrestin 1 and 2 [21, 22]

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