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Xi Chen is that we can maximize the utility of our model to derive effective intrinsic molecular biomarkers for TNT response by strategically combining genomic data from tumoroids and matched primary tumors of RC patients ( Lastly, as an active clinical trialist and Chair of the National Phase II now Phase III trial (The Janus Rectal Cancer Trial – opened 9 November 2022 – NCT05610163 (n= 776/760 patients (now completed as of 2 July 2025)) that was built on the findings from the OPRA trial, I am well positioned to ask and answer relevant translational and clinical research questions to improve outcomes for RC patients