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Painful sores inside the mouth Cracked, red skin at the corners of the lips Pale or Yellowish Skin Tone A B12 deficiency may impair red blood cell production, leading to: A washed-out or pale appearance Sometimes a mild yellowing of the skin due to megaloblastic anemia Other (Non-Skin) Symptoms to Watch For Even if skin issues are your main concern, B12 deficiency rarely happens in isolation