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Moreover, the therapeutic use of butyrate has been demonstrated to revert manic-like behavior in rats and regulates the antioxidant enzyme activities, protecting the brain against oxidative damage [207] therefore supporting the important role that SCFAs may play in the brain alterations in patients with BD

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When speaking to your GP or prescriber, it may be helpful to: Keep a symptom diary noting when nausea occurs, how long it lasts, and any potential triggers Describe the severity of your symptoms honestly, including whether they are affecting your daily life or ability to eat and drink Mention any other medicines you are taking, as interactions may occasionally contribute to gastrointestinal symptoms Ask about dose adjustment if symptoms are persistent or distressing If you develop severe or worsening abdominal pain, are unable to keep fluids down, or experience any of the red-flag symptoms described in the section above, contact NHS 111 for urgent advice or call 999/go to A&E if symptoms are severe