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It is present in nearly all bodily fluids: cerebrospinal fluid, saliva, bile, synovial fluid, amniotic fluid, urine, feces, semen, and breast milk [16,19,20]

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To evaluate the hepatic metabolism of the substances tested, the main Cyp450 isoforms, Cyp1A2 and Cyp3A4, as well as Src and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK), were also examined