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DUAL GLUCAGON/GLUCAGON-LIKE PEPTIDE-1 RECEPTOR CO-AGONISTS As part of the ongoing effort to use synergistic effects of gastrointestinal hormones in the treatment of diabetes and obesity, the first GIP/GLP-1 receptor co-agonist was reported in 2013

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This process necessitates systematic phase I clinical trials designed to characterize pharmacokinetics, assess tolerability and establish the maximum tolerated dose in human subjects (173)