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Mechanistically, some evidence on the autophagic machinery demonstrated that SIRT1 participates in autophagy via deacetylating TFEB (transcription factor EB), LC3 (microtubule associated protein 1 light chain 3), Beclin-1, p62, ATG5 (autophagy-related gene 5), ATG7 (autophagy-related gene 7), and ATG8 (autophagy-related gene 8) in a NAD+-dependent manner [40, 41]