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Without adequate levels of B12 and folate, red blood cells enlarge, and macrocytic anemia can occur, although women won’t always reach the anemia state

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Metabolic diseases In addition to muscle and neurodegenerative conditions, alterations in NAD + levels and mitochondrial homeostasis are also observed in aging-associated metabolic diseases, particularly those conditions impacting highly mitochondrially-active tissues such as the kidney and liver 292–294