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Your point highlights the real challenge: when someone is already training intelligently, sleeping well, and adjusting nutrition, it becomes very difficult to isolate the molecule’s contribution

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Nrf2 induces the expression of several cytoprotective proteins, including NAD(P)H quinine oxidoreductase (NQO1), glutamate-cysteine ligase catalytic subunit and modifier subunit (GCLC and GCLM), and heme oxygenase-1 (HO-1) (Baird and Dinkova-Kostova, 2011)