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The following gradient conditions were used: 5–15 % (0–40 min), 60 % B (40–65 min), 95 % B (65–75 min), 95 % B (75–80 min) and 5 % B (80·1–100 min)

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These peripheral and central deficits can include severe gastrointestinal lesions, intracranial (superior sagittal sinus) hypertension, brain swelling and lesions, portal and caval hypertension, aortic hypotension, peripheral and central thrombosis, inferior caval vein and superior mesenteric vein congestion, azygos vein failure, electrocardiogram (ECG) disturbances, and heart, lung, liver, and kidney lesions (Vukojevic et al., 2018