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PKA is also a potent inflammation resolving factor being reduced in acute phase of inflammation by increased PDE4 activity (breaking cAMP to AMP) (184) and being active when the inflammation finishes thus activating other resolving molecules (184, 185) and activating phagosomes (186)

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Similarly, certain flavonoids like quercetin have been reported to inhibit metabolizing enzymes when co-administered with specific compounds, potentially prolonging their half-lives and enhancing therapeutic efficacy (279)