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Even though different mechanisms of the KD have been reviewed the last few years (15, 17, 18, 20, 56) (i.e., focusing on the primary antiseizure mechanisms), we have compiled a comprehensive overview of the ancillary pathways that are affected by the KD and discussed their pre-clinical and clinical evidence in epilepsy treatment

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• IV delivery maximizes effectiveness : Intravenous administration achieves 100% bioavailability compared to oral supplements' 2-10% absorption rate for both compounds