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Published in Pharmaceuticals (PMID: 38675421), this 41-page open-access review proposes that BPC-157, while not meeting classical neurotransmitter criteria, functions as a cytoprotection mediator with neurotransmitter-like activity through a “network of interconnected evidence.” What Makes BPC-157 Unique BPC-157 is a 15-amino acid peptide (sequence: GEPPPGKPADDAGLV, molecular weight 1419) native and stable in human gastric juice for over 24 hours, showing no sequence homology with known gut peptides

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Iterative model building and refinement were carried out in a cyclic manner using phenix.refine 62 within the PHENIX suite, BUSTER-TNT , 63 and COOT 64 until a complete model was built and refinement convergence achieved