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Figure 3 Pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma (PADC) is common malignant and poor prognosis tumors with a 5-year survival rate of approximately 10% in the USA ( KRAS -triggered PDAC growth is accompanied by the metabolic rewiring of Gln metabolism, which fulfills the NADPH need and balances cellular oxidative homeostasis ( Acute myeloid leukemia Several recent studies have demonstrated that Gln metabolism is implicated in the progression of acute myeloid leukemia (AML), as evidenced by exerting antileukemic effects ( in vivo mouse models of AML ( Non-small cell lung cancer In general, radiotherapy alone or in combination with chemotherapy and adjuvant durvalumab are mainly therapeutic methods for patients with locally advanced non-small cell lung cancer (NSCLC) ( in vitro and in vivo ( Hepatocellular carcinoma Liver cancer stem cells (CSCs), a subset of liver cells with stem cell features, are considered to be responsible for hepatocellular carcinoma (HCC) recurrence, metastasis, and chemoresistance ( via its agonist SKL2001 could upregulate the mRNA and protein levels of GLS1, and then promote Gln metabolism, which means that activated Wnt/β-catenin pathway could promote GLS expression with positive feedback ( Prostate cancer Prostate cancer (Pca) treatments, such as radiation, chemotherapy, and hormone therapy, can induce autophagy that improves therapeutic resistance (73)
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A novel role for BRIP1/FANCJ in neuronal cells health and in resolving oxidative stress-induced DNA lesions
