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The expression of two essential pentose phosphate pathway enzymes, glucose-6-phosphate dehydrogenase (G6PD) and phosphogluconate dehydrogenase (PGD), significantly declined in the HIF-1α knockdown group

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We suggest that translational arterial stiffness research should (i) improve clinical assessment, (ii) identify specific pheno- and endotypes, (iii) decipher underlying mechanisms and “new” risk factors (e.g., chronic psychosocial stress, air pollution), and (iv) develop tailored prevention and therapy approaches (Fig