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FIGURE 2 FIGURE 3 4.6 Anti-fibrosis Intestinal fibrosis is considered a common pathological feature of UC and represents a long-term complication characterized by excessive proliferation of myofibroblasts and collagen deposition (Rieder et al., 2017

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Acknowledgements This work has been supported by National Natural Science Foundation of China grants (W2412122, 82470195, 82200208), Natural Science Foundation of Tianjin grants (24JCYBJC00780, 24ZXZSSS00050), State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine grants (QZ 23-6, 23-4), Jin Men Medical Talents of Tianjin (TJSJMYXYC-D2-039), Clinical Oncology Research Fund of CSCO grant (Y-2024AZ(BTK)MS-0040) and Tianjin Key Medical Discipline (Specialty) Construction Project grant (TJYXZDXK-009A)

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