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While, mast cell produced IL-13 is considered to have anti-inflammatory in Th1 hapten CHS models limiting the production CD4 + IFN-γ + cells in the skin 52 , for IgE-mediated allergic skin disorders, IL-13 is proinflammatory promoting Th2 cytokine production, disrupting the skin barrier and causing epidermal hyperplasia 52,81