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ME involves a vulnerable or intermittently leaky Blood–Brain Barrier (BBB). When the BBB becomes permeable, immune molecules, toxins, and oxidative byproducts enter the brain and trigger neuroinflammation, impaired blood flow, sensory dysfunction

Our previous study in male mice proved that supplementary dietary TMAO exacerbated IR in high fat diet induced obese mice by inducing chronic inflammation in adipose tissue and blocking insulin signaling pathway conduction, while it has no effect on normal mice (12)

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Only if you're a qualified prescriber