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DAMPs bind and activate pattern recognition receptors (PRRs) on Kupffer cells, including Toll-like receptor 4 (TLR4), which is upregulated in NASH livers, leading to nuclear translocation of a master transcriptional regulator of inflammation, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) (161)

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10.1111/2041-210X.12309 18