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Comparison of the SLC25A45 amino acid sequence across species and its alignment with other yeast and human carriers 28 , 61 indicated that serine 65, arginine 173, and arginine 268 are potential substrate contact points in the central cavity of human SLC25A45 (Figures 3D and S5)

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Because PFKFB3 is upregulated in EGFR-TKI resistant NSCLC, PFK15 exhibits synergistic impact with erlotinib in wild type and EGFR mutant cell lines (Lypova et al., 2019)