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It activates ILK (integrin-linked kinase) and AKT signaling It increases VEGF (vascular endothelial growth factor) expression to support angiogenesis It enhances tissue remodeling It reduces inflammatory signaling through NF-κB suppression It lowers pro-inflammatory cytokine activity in injury models A landmark study published in Nature demonstrated Tβ4 activates integrin-linked kinase and promotes cardiac cell migration, survival, and cardiac repair