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OXCT1 (3-oxoacid CoA-transferase 1), also known as succinyl-CoA:3-ketoacid coenzyme A transferase (SCOT), serves as the rate-limiting enzyme for ketone body utilization in extra-hepatic tissues such as skeletal muscle, cardiac muscle, and brain [33]

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This mechanism has lately been extensively studied in metabolic diseases, and the mitochondria and lysosome contact sites have been found to be related to the exchanges of various metabolites such as calcium, cholesterol, iron (Wong et al., 2018)