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Second, current experiments rely on standardized animal models and do not fully reflect clinical heterogeneity, including differences in injury level, severity, and comorbidities and lack validation in human tissue samples

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Huichia Chao, Shintaro Yoshida, and Masanori Kohmura International Glutamate Technical Committee (IGTC) National Press Building 529, 14th Street, Suite 1280, Washington, DC 20045, USA Competing interests HC, SY are the secretaries and MK is the CEO of IGTC, a worldwide research organization having NGO status