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Glutathione oxidation in cerebrospinal fluid as a biomarker of oxidative stress in amyotrophic lateral sclerosis | Translational Neurodegeneration | Springer Nature Link
Beside the sources of ROS mentioned above, there are also many ROS-generating enzymes include succinate dehydrogenase (SDH) (37), dihydroorotate dehydrogenase (DHOH) (38), mitochondrial glycerol-1-phosphate dehydrogenase (mGPDH) (39), cytochrome b5 reductase (40), monoamine oxidases (MAOs) (41), aconitase (ACO) (42), xanthine oxidoreductase (XOR) (43), alpha-Ketoglutarate dehydrogenase complex (KGDHC) (44), and so on
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GSTs catalyze the conjugation of acrolein to GSH and the corresponding conjugate is further modified by the enzymatic cleavage of the GSH glutamic acid and glycine residues by γ-glutamyltranspeptidase and cysteinylglycinase, respectively