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4 Limitations of Berberine Treatment Berberine has a variety of activities that may be involved in alleviating Alzheimer’s disease, including antioxidant, neuroprotective, and anti-inflammatory effects (Rabbani et al., 1987), it is generally considered to be non-genotoxic and cytotoxic in clinical (Imanshahidi and Hosseinzadeh, 2008)

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