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Clinical trials have demonstrated that patients with stage IIIb-IV chronic kidney disease (CKD) exhibit the accumulation of enterogenous uremic toxins (UT), such as indoxyl sulfate (IS) and p-toluene sulfate (PCS), along with increased intestinal permeability and constipation (Cosola et al., 2021)

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Data from both primary human T-cells and the Jurkat T-cell line showed that high levels of dopamine (10 −4 M) significantly increased HIV replication by activating NF- κ B and Sp1 binding sites in the HIV long terminal repeat (Rohr, Sawaya et al., 1999)