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These accumulated lipids release free fatty acids and pro-inflammatory cytokines, leading to systemic, low-grade, subclinical chronic inflammation associated with insulin resistance, exacerbating ectopic fat deposition and metabolic dysfunction, ultimately affecting renal, hepatic, cardiovascular, and endocrine health [7,9,10,11,12]

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Additionally, the release of cytokines and chemokines perpetuates inflammation by recruiting other immune players, including B cells and natural killer (NK) cells