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From this perspective, PDE5i may contribute not only to acute erectile facilitation but also to the long-term maintenance of erectile tissue physiology, effectively acting as sustainers of cavernosal tissue health [10]

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NRF2 protein stability is tightly regulated and its two main regulators are i) Kelch-like ECH-associated protein 1 (KEAP1) in the cytoplasm and ii) BTB and CNC homology 1 (BACH1) in the nucleus