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In addition, under the context of studying central trained immunity as a basis for inflammatory comorbidities, experimental periodontitis-induced central trained immunity could be transferred to healthy mice via bone marrow transplantation, leading to more severe arthritis in a collagen antibody, induced arthritis model (82)

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Recent research underscores the vital roles of lactate in enhancing memory impairments, alleviating neurological dysfunctions, and fostering neuronal repair and regeneration [8]