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Of note, Trm cells have been identified as members of CD8+ tumor infiltrating lymphocytes (TILs) in patients with various solid tumors, and a Trm cell gene signature has been associated with a favorable prognosis and an increased likelihood of a response to anti-PD1 therapy in lung, breast, and melanoma cancers (48)

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However, the highest 15-year cumulative incidence of death in patients with MASLD was for extrahepatic cancer (7.9%) and cardiovascular disease (7.2%)