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The History and Development of AOD-9604 The development of the AOD-9604 peptide stems from a desire to isolate the fat-burning properties of human growth hormone without triggering its other physiological effects

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Prostate cancer cells co-cultured with adipocytes increase expression of IL1-β to stimulate adipocyte lipolysis in a vicious positive feedback loop that decreases prostate cancer cell sensitivity to docetaxel and upregulates prostaglandin E2 (PGE2) synthesis in adipocytes, a prostate cancer pro-survival signal (212)